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Table 6 Antitumor effects of Raz on Lewis lung carcinoma in combination with bleomycin: * Administrate every 3 hours in one day. ** p < 0.01 (treatment vs vehicle control). Experimental term was 11 days

From: Antitumor effects of two bisdioxopiperazines against two experimental lung cancer models in vivo

Compounds

Dosage

Schedule

Tumor weight

Tumor Inhibition

 

mg/kg

1, 5, and 9 administration

(g)

%

Control

--

--

2.46 ± 0.06

 

Razoxane (Raz)

10

3 times a day*

1.44 ± 0.07

41.5

Bleomycin (Ble)

15

1 time a day

1.50 ± 0.06

39.0

Raz + Ble

10 + 15

3 times + 1 time a day

0.66 ± 0.05**

73.2**