Table 5 Antitumor effects of Raz on Lewis lung carcinoma in combination with daunorubicin: *Administration every 3 hours. Experimental term was 11 days
From: Antitumor effects of two bisdioxopiperazines against two experimental lung cancer models in vivo
Compounds | Dosage | Schedule | Tumor weight (g) | Tumor inhibitions |
|---|---|---|---|---|
mg/kg | 1, 5, and 9 administrations | % | ||
Control | 2.34 ± 0.05 | |||
Razoxane (Raz) | 10 | 3 times a day* | 1.57 ± 0.05 | 32.9 |
Daunorubicin (Dau) | 2 | 1 time a day | 1.10 ± 0.04 | 53.0 |
Raz + Dau | 10 + 2 | 3 times/1 time a day | 1.02 ± 0.04 | 56.4 |