Table 3 The influence of Pro and Raz on primary and metastatic tumor of LLC: PTI (%) – Primary tumor inhibition. MFCPM – metastatic foci count per mouse. Route: ip × 7 every 2 days. Experiment term was 20 days, * P < 0.001(treatment vs vehicle control). The numbers of mice were 30 for both control group and each treatment group. 100 % survival was observed in each group.
From: Antitumor effects of two bisdioxopiperazines against two experimental lung cancer models in vivo
Compounds | Dosage mg/kg/d | Body weigh (g) | PTI(%) | MFCPM |
|---|---|---|---|---|
Control | --- | 22.8/21.4 | -- | 30.9 ± 7.3 |
Razoxane | 20 | 22.7/21.5 | 40.3 | 1.2 ± 0.5* |
Probimane | 30 | 23.3/22.5 | 42.0 | 1.5 ± 0.5* |
Probimane | 60 | 23.3/20.3 | 48.0 | 1.0 ± 0.2* |