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Table 3 Selected genes induced or repressed by exposure of pMJ1-transformed yeast cells to equitoxic concentrations of ICRF-187 and m-AMSA for 2 hours

From: Characterisation of cytotoxicity and DNA damage induced by the topoisomerase II-directed bisdioxopiperazine anti-cancer agent ICRF-187 (dexrazoxane) in yeast and mammalian cells

Transcriptional activation

Gene function

Gene Name

Effect of ICRF-187

Effect of m-AMSA

DNA damage

RNR3

3.2

4.0

 

HUG1

3.1

5.0

 

RAD51

1.9

2.0

 

RAD54

1.7

1.6

 

RNR2

1.5

1.8

Membrane transport

PDR12

2.4

1.0

 

PDR15

2.0

1.0

Stress response

HSP12

2.8

1.6

 

HSP26

1.7

1.8

 

WSC4

1.6

1.3

 

XBP1

1.6

1.5

 

HSP42

1.5

1.5

Others

SWI1

1.6

1.1

Transcriptional repression

   

Others

SNZ1

0.6

1.1

 

PCL9

0.7

0.6