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Figure 4 | BMC Pharmacology

Figure 4

From: Characterisation of cytotoxicity and DNA damage induced by the topoisomerase II-directed bisdioxopiperazine anti-cancer agent ICRF-187 (dexrazoxane) in yeast and mammalian cells

Figure 4

Assessing the effect of equitoxic concentrations of ICRF-187 and m-AMSA on the level of HR in SPD8 hamster cells. The SPD8 cell line has a defective hprt gene that can be repaired by HR. Panel A depicts the induction of HR induced by increasing concentrations of the two drugs. Panel B depicts the relative survival of cells exposed to similar concentrations of the two drugs. The data represented in Panel A and B was used to generate Panel C, where recombination frequency is plotted against the surviving fraction of cells. This data presentation allows a direct comparison of recombination levels at equitoxic concentrations of the two drugs. Representative data from one of three independent experiments is shown.

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BMC Pharmacology

ISSN: 1471-2210