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Figure 3 | BMC Pharmacology

Figure 3

From: Characterisation of cytotoxicity and DNA damage induced by the topoisomerase II-directed bisdioxopiperazine anti-cancer agent ICRF-187 (dexrazoxane) in yeast and mammalian cells

Figure 3

Assessing the clonogenic sensitivity of HR and NHEJ deficient and proficient hamster cells towards ICRF-187 and m-AMSA. To determine the sensitivity of the four cell lines AA8 (wild-type), irs1SF (recombination defective caused by non-functional XRCC3), CXR3 (recombination proficient due to ectopic expression of human XRCC3), and V3-3 (defective in NHEJ due to non-functional DNA-PKcs) towards ICRF-187 and m-AMSA, a clonogenic assay with continuous drug exposure was used. Error-bars represent SEM of two independent experiments.

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BMC Pharmacology

ISSN: 1471-2210