Reserpine methonitrate, a novel quaternary analogue of reserpine augments urinary excretion of VMA and 5-HIAA without affecting HVA in rats

Table 1 Effect of reserpine and reserpine methonitrate on the mean arterial pressure of anaesthetized rats.

Drug	Dose (μg/kg)	Mean arterial pressure (mmHg, n = 6)			Reduction due to drug
		Before drug	After drug	Mean reduction
Vehicle	0.05 ml	126.2 ± 2.8	110.0 ± 4.1	16.2 ± 1.4	---
Reserpine	0.25	138.3 ± 4.6	119.5 ± 4.2	18.8 ± 1.4^NS	2.6
	0.50	134.1 ± 5.5	91.2 ± 5.0	42.9 ± 0.9**	26.5
	1	135.2 ± 4.7	80.5 ± 3.8	54.8 ± 1.6**	38.6
	5	130.5 ± 5.1	69.0 ± 3.5	61.5 ± 2.8**	45.3
	10	130.0 ± 4.2	58.7 ± 3.9	71.2 ± 1.3**	55.0
	15	131.5 ± 5.1	41.1 ± 2.9	90.4 ± 3.1**	74.2
Reserpine methonitrate equivalent to reserpine	10	128.8 ± 6.4	90.0 ± 9.1	38.8 ± 3.6**	22.6
	25	135.0 ± 8.5	73.0 ± 7.4	62.0 ± 2.8**	45.8
	50	136.8 ± 5.3	42.5 ± 3.7	93.0 ± 8.0**	76.8