TY - JOUR AU - Sreemantula, Satyanarayana AU - Boini, Krishna M. AU - Nammi, Srinivas PY - 2004 DA - 2004/11/16 TI - Reserpine methonitrate, a novel quaternary analogue of reserpine augments urinary excretion of VMA and 5-HIAA without affecting HVA in rats JO - BMC Pharmacology SP - 30 VL - 4 IS - 1 AB - Reserpine, an alkaloid from Rauwolfia serpentina was widely used for its antihypertensive action in the past. In later years, its use has been reduced because of precipitation of depression and extra pyramidal symptoms due to its central action. In the present investigation, reserpine methonitrate (RMN), a novel quaternary analogue of reserpine was synthesised and evaluated biochemically for its central and peripheral amine depleting actions in rats while its influence on the blood pressure was measured in anaesthetized rats in comparison with reserpine SN - 1471-2210 UR - https://doi.org/10.1186/1471-2210-4-30 DO - 10.1186/1471-2210-4-30 ID - Sreemantula2004 ER -