Figure 2

Time spent treading water (i.e., not making forward progress) during the P18 water maze test. There was a general decline in the time spent treading water as the animals learned the maze. Ketamine-treated rats spent the least time exhibiting this behavior. Rats treated with the NMDA-receptor blocking drug on E18 stopped swimming for the shortest period and made more-constant progress towards the hidden platform. Data were analyzed using a three-way ANOVA [Drug (100 mg/kg ketamine HCl, saline control) X Treatment age (E18, E19) X Time] with time blocks as the repeated time factor and compensation for unequal Ns. Variance indicators are the Standard Error of the Mean (SEM).