Figure 4

Effect of indomethacin and PACs on cytokines release in pleural exudate. Pleural injection of carrageenin caused by 4 h an increase in the release of the cytokines, tumor necrosis factor alpha (TNF-α, A), interleukin-1β (IL-1β, B), interleukin-6 (IL-6, C), interleukin-10 (IL-10, D) and cytokine-induced neutrophil chemoattractant-1 (CINC-1, E). TNF-α, IL-1β and CINC-1 levels were reduced by PACs, but IL-6 and IL-10 levels were not modified. Indomethacin lowered the level of all these cytokines. Each value is the mean ± s.e. mean of n = 6 experiments. °P < 0.05 versus sham. *P < 0.05 versus carrageenin.