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Figure 6 | BMC Pharmacology

Figure 6

From: Reduced inhibitory action of a GABAB receptor agonist on [3H]-dopamine release from rat ventral tegmental area in vitro after chronic nicotine administration

Figure 6

Effect of baclofen on the electrically evoked release of [3H]-DA from VTA slices of rats pretreated with nicotine or saline. The rats received daily subcutaneous injections of nicotine (0.4 mg kg-1, n = 5) or saline (n = 5) for 14 consecutive days and the experiments were performed 24 hours after the last injection. Two electrical stimulations (20 mA, 2 Hz, 4 min) were applied to the slices 14 min (S1) and 59 min (S2) after the beginning of sample collection. Baclofen (10 μM) was added to the superfusion buffer 36 min before and during S2. Control tissue was perfused with buffer alone during both S1 and S2. Data are expressed as mean ± s.e.mean and compared by ANOVA for repeated measures. **p < 0.01 vs saline-control (Bonferroni post-test).

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