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Figure 5 | BMC Pharmacology

Figure 5

From: Reduced inhibitory action of a GABAB receptor agonist on [3H]-dopamine release from rat ventral tegmental area in vitro after chronic nicotine administration

Figure 5

Effect of nicotine pre-treatment on basal and electrically evoked release of [3H]-DA from VTA slices. The rats received daily subcutaneous injections of nicotine (0.4 mg kg-1, n = 6) or saline (n = 6) for 14 consecutive days and the experiments were performed 24 hours after the last injection. An electrical stimulation (20 mA, 2 Hz, 4 min, black bar) was applied to the VTA slices 14 min after the beginning of sample collection. The data are expressed as fractional [3H]-DA release and represented as mean ± s.e.mean.

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BMC Pharmacology

ISSN: 1471-2210