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Figure 4 | BMC Pharmacology

Figure 4

From: Reduced inhibitory action of a GABAB receptor agonist on [3H]-dopamine release from rat ventral tegmental area in vitro after chronic nicotine administration

Figure 4

Reversal of baclofen-mediated inhibition of the evoked [3H]-DA release from VTA slices by the GABAB antagonist CGP55845A. Baclofen (Bacl, 10 μM) and/or CGP55845A (CGP, 1 μM) were added to the superfusion buffer 36 min before and during S2. Drug effects were assessed by comparing the ratio S2/S1 in the presence and absence of the drug, respectively. Values represent mean ± s.e.mean (n = 6–10 rats). *p < 0.05 vs control (one-way ANOVA, Dunnett's post hoc test).

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BMC Pharmacology

ISSN: 1471-2210