Table 3 Effect of pioglitazone and GW347845 in ZDF rats.
|  | Insulin (ng/ml) | Glucose (mg/dL) | Triglycerides (mg/dL) | FFA (mEq/L) | Adiponectin (μg/ml) |
|---|---|---|---|---|---|
ZDF lean rats | |||||
Vehicle | 0.3 ± 0.1 | 158 ± 4 | 82 ± 7 | 0.31 ± 0.02 | 10.2 ± 0.5 |
ZDF rats | |||||
Vehicle | 2.9 ± 0.5** | 525 ± 25** | 912 ± 97** | 0.62 ± 0.03** | 10.0 ± 1.1 |
Pioglitazone (mg/kg, B.I.D) | |||||
3 | 2.5 ± 0.6+ | 214 ± 64+ | 251 ± 81++ | 0.26 ± 0.09++ | 44.0 ± 7.7++ |
10 | 2.8 ± 0.5 | 154 ± 17++ | 129 ± 19++ | 0.16 ± 0.01++ | 60.0 ± 1.5++ |
30 | 2.3 ± 0.4+ | 154 ± 9++ | 129 ± 16++ | 0.14 ± 0.01++ | 63.0 ± 0.8++ |
GW347845 (mg/kg, B.I.D) | |||||
3 | 1.7 ± 0.2++ | 147 ± 6++ | 95 ± 10++ | 0.12 ± 0.01++ | 66.1 ± 0.6++ |