Serum adiponectin as a biomarker for in vivo PPARgamma activation and PPARgamma agonist-induced efficacy on insulin sensitization/lipid lowering in rats

Table 2 Effect of GW347845 (3 mg/kg, B.I.D.) in rats on HF diet.

	Triglycerides (mg/dL)	FFA (mEq/L)	Serum Insulin (ng/ml)	Insulin AUC (min × ng/ml)
Normal diet	98.6 ± 8.6	0.26 ± 0.03	1.34 ± 0.19	241.0 ± 22.8
Diet-Vehicle	455.6 ± 94.2**	0.65 ± 0.07**	1.88 ± 0.16*	356.9 ± 25.3**
Diet-GW347845	139.4 ± 14.8++	0.37 ± 0.03++	1.16 ± 0.08++	267.9 ± 34.2
Corr. Coeff.	-0.637	-0.6877	-0.5512	-0.3812
Vs adiponectin	p < 0.01	p < 0.01	p < 0.01	p < 0.05

Corr. Coeff.: Pearson Correlation Coefficient. *p < 0.05 vs Normal diet. **p < 0.01 vs normal diet. ⁺⁺p < 0.01 vs diet-vehicle. N = 7–8 in each group.