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Table 3 Histamine release from HMC-1 cells stimulated with varying concentrations of sulfite-only solutions in the presence of prostaglandin H synthetase. Histamine release expressed as a percentage of release of histamine in comparison to control (SD). As a control, the HMC-1 cells were allowed to freeze and thaw for 3 cycles to release the remaining histamine from cells. Each value represents the mean (SD) of triplicate determinations.

From: In vitro evaluation of the potential role of sulfite radical in morphine-associated histamine release

Sulfite concentration (ng/ml)

Histamine release (% total)

0.018

2.8 (0.3)

0.45

1.93 (0.35)

7

4.5 (0.7)

670

9.7 (0.65)