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Table 2 Histamine release from HMC-1 cells stimulated with varying concentrations of morphine with and without sulfite in the presence of prostaglandin H synthetase. Histamine release expressed as a percentage of release of histamine in comparison to control (SD). As a control, the HMC-1 cells were allowed to freeze and thaw for 3 cycles to release the remaining histamine from cells. Each value represents the mean (SD) of triplicate determinations.

From: In vitro evaluation of the potential role of sulfite radical in morphine-associated histamine release

Morphine concentration (μg/ml)

Histamine release (% total)* Sodium bisulfite

 

+

-

0

 

2.9 (2.6)

0.018

3.3 (2.9)

4.5 (1.4)

0.450

6.5 (0.9)

6.7 (1.8)

6.68

8 (0.3)

6.2 (1.5)

668

17.6 (7.8)

16.1 (6.3)