Table 1 Histamine release from HMC-1 cells stimulated with varying concentrations of morphine with and without sulfite Histamine release expressed as a percentage of release of histamine in comparison to control (SD). As a control, the HMC-1 cells were allowed to freeze and thaw for 3 cycles to release the remaining histamine from cells. Each value represents the mean (SD) of triplicate determinations.
Morphine concentration (μg/ml) | Histamine release (% total)* Sodium bisulfite | |
|---|---|---|
+ | - | |
0 | 2.9 (2.6) | |
0.018 | 2.5 (0.75) | 3.2 (1.1) |
0.450 | 1.7 (0.4) | 2.6 (0.4) |
6.68 | 1.8 (0.6) | 2.2 (1.3) |
668 | 2.1 (0.06) | 2.8 (0.2) |