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Figure 3 | BMC Pharmacology

Figure 3

From: Peroxynitrite decomposition catalyst ameliorates renal damage and protein nitration in cisplatin-induced nephrotoxicity in rats

Figure 3

Representative histological abnormalities in the external cortical kidney area after three days of cisplatin administration and their partial prevention by FeTPPS. (A) Normal kidney histology from control rat. (B) After three days of cisplatin administration, many cortical convoluted tubules are revisted by necrotic epithelial cells (arrows) or vacuolated swell cells (arrow heads), glomeruli do not show apparent damage. (C) FeTPPS administration does not produce histological kidney abnormalities. (D) The administration of FeTPPS partially prevents the cytotoxic damage induced by cisplatin; arrows indicate middle cellular vacuolization of cortical convoluted tubules.

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