(A) Serum creatinine and (B) BUN on day 3 in the four groups of rats studied. Ct: control group, Cis: cisplatin group; FeTPPS: 5,10,15,20-tetrakis(4-sulfonatophenyl) porphyrinato iron (III) group, and Cis+FeTPPS: cisplatin+5,10,15,20-tetrakis(4'-sulfonatophenyl) porphyrinato iron (III) group. Data are mean ± SEM. n = 6. aP < 0.001 vs. Ct; bP < 0.001 vs. Ct, cP < 0.05 vs Cis (Panel A); aP < 0.001 vs. Ct; bP < 0.001 vs. Ct, cP < 0.001 vs Cis (Panel B). Serum creatinine and BUN increased in cisplatin group and FeTPPS prevented these increases in the Cis+FeTPPS group.