Table 1 Agonist Pharmacology in HEK and L-cells.
From: Extrinsic factors regulate partial agonist efficacy of strychnine-sensitive glycine receptors
GlyR α2 | GlyR α2β | |||||
|---|---|---|---|---|---|---|
System | log EC50 | EC50 (mM) | Efficacya | log EC50 | EC50 (mM) | Efficacy |
Glycine | ||||||
HEK | -3.67 ± 0.15 | 0.22 | -- | -3.55 ± 0.06 | 0.28 | -- |
L-cells | -3.36 ± 0.05 | 0.43 | -- | -3.17 ± 0.04 | 0.67 | -- |
β-Alanine | ||||||
HEK | -3.12 ± 0.05 | 0.76 | 0.80 ± 0.06 | -3.24 ± 0.03 | 0.57 | 0.55 ± 0.07 |
L-cells | -2.71 ± 0.08b | 1.93 | 0.39 ± 0.08 | -2.59 ± 0.13 | 2.59 | 0.25 ± 0.05 |
Taurine | ||||||
HEK | -3.13 ± 0.12 | 0.74 | 0.48 ± 0.12 | -2.67 ± 0.12 | 2.20 | 0.32 ± 0.05 |
L-cells | ≥-3.00 ± 0.11c | 1.00 | 0.06 ± 0.01 | ≥-2.97 ± 0.20c | 1.10 | 0.05 ± 0.01 |