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Figure 12 | BMC Pharmacology

Figure 12

From: A study comparing the actions of gabapentin and pregabalin on the electrophysiological properties of cultured DRG neurones from neonatal rats

Figure 12

Pregabalin produced delayed enhancement of K+ currents in cultured DRG neurones. A) Line graph showing a time course for the delayed action of pregabalin in a single neurone, the open bar shows the period of application of pregabalin (250 μM). Little effect of pregabalin was seen in this neurone until 5 minutes after removal of the pressure ejection pipette containing pregabalin. B) Inset traces show a control K+ current activated at +40 mV, modest enhancement of the K+ current after 5 minutes application of 250 μM pregabalin and the enhanced outward K+ current recorded 9 minutes after application of pregabalin. Apamin mimicked the inhibitory action of pregabalin on K+ current but did not prevent enhancement of the K+ current by acute application of 250 μM pregabalin. C) Bar chart showing the modest inhibitory effect of apamin (1 μM) on K+ current and the enhancement in K+ current when pregabalin was applied in the continued presence of apamin (Apamin & PGB). D) Traces showing a control K+ current, the inhibited K+ current in the presence of 1 μM apamin and the enhanced K+ current observed when apamin and pregabalin were applied together. Apamin prevented the inhibitory effect of pregabalin but not the enhancement of K+ current.

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BMC Pharmacology

ISSN: 1471-2210