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Figure 11 | BMC Pharmacology

Figure 11

From: A study comparing the actions of gabapentin and pregabalin on the electrophysiological properties of cultured DRG neurones from neonatal rats

Figure 11

Acute application of gabapentin produced modest inhibition of voltage-activated K+ currents in cultured DRG neurones but long-term measurement of K+ currents shows a delayed enhancement in outward current. A) Bar chart showing data for the acute (3–5 minutes) reversible inhibition of the mean K+ current by 250 μM gabapentin (GBP). B) Traces showing a control outward K+ current activated at 0 mV and the inhibited current activated at the same voltage after 3 minutes application of 250 μM gabapentin (GBP). C) Traces showing the biphasic response to 250 μM gabapentin. Illustrated are the control current, the inhibited current recorded after 5 minutes application of gabapentin (GBP) and the enhanced outward current measured 5 minutes after removal of the perfusion pipette containing gabapentin (Enhanced Current).

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BMC Pharmacology

ISSN: 1471-2210