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Figure 10 | BMC Pharmacology

Figure 10

From: A study comparing the actions of gabapentin and pregabalin on the electrophysiological properties of cultured DRG neurones from neonatal rats

Figure 10

Pregabalin modulates voltage-activated potassium currents in cultured DRG neurones. A) Traces showing that 2.5 μM pregabalin failed to significantly alter the outward K+ current evoked by a 100 ms voltage step command from -90 mV to 40 mV. B) Current / voltage relationship showing enhancement of outward current following 3 minutes application of 250 μM pregabalin (filled circles = control data and open circles currents recorded in the presence of pregabalin (PGB); * = P < 0.05 & ** = P < 0.01). Inset traces show the control outward K+ current activated at +40 mV and the enhanced K+ current recorded in the presence of pregabalin (250 μM). C) Current / voltage relationship showing inhibition of outward K+ current following 3 minutes application of 250 μM pregabalin (filled circles = control data and open circles K+ currents recorded in the presence of pregabalin (PGB); * = P < 0.05). Inset traces show the control outward K+ current activated at +40 mV and the attenuated K+ current recorded in the presence of pregabalin (250 μM).

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BMC Pharmacology

ISSN: 1471-2210