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Figure 2 | BMC Pharmacology

Figure 2

From: 8-Cl-Adenosine enhances 1,25-dihydroxyvitamin D3-induced growth inhibition without affecting 1,25-dihydroxyvitamin D3-stimulated differentiation of primary mouse epidermal keratinocytes

Figure 2

8-Cl-Ado and 1,25(OH) 2 D 3 Act Additively to Inhibit Keratinocyte Proliferation. Near-confluent primary mouse epidermal keratinocytes were treated with the indicated concentrations of 8-Cl-Ado in the presence of no (closed circles), 1 nM (open squares) or 10 nM (open triangles) 1,25(OH)2D3 for 24 hours, and [3H]thymidine incorporation was determined as indicated in Materials and Methods. Data represent the mean ± SEM of five experiments performed in triplicate; *p < 0.05, **p < 0.01 versus the control value, †p < 0.01 versus the corresponding concentration of 1,25(OH)2D3 alone, §p < 0.01 versus the corresponding concentration of 8-Cl-Ado alone.

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