Skip to main content

Table 3 Effects on position and steepness of concentration-saturation relationships when varying single independent system constants. Parameter values were typically varied between 10-4 to 104. Except for indicated variations in a, the table is collected for parameter a = 100.

From: A homotropic two-state model and auto-antagonism

increasing value of parameter

move mono-phasic dose-binding curves to

Hill coefficient of dose-binding curves may go from

a

left

<1 → ~1

b

left

<1 → ~1

c

left

1 → 2

d

left

<1 → ~1

A S

left

1 → 2

A M

left

1 → 2

L for AS > 1

left

1 → 2

L for AS & b < 1

right*

1, for d >> 1 1 → 2

  1. * for d >>> 1 may go left