Table 2 Dose-response shapes for functional-HOTSM, when varying b, b·d, and A M . AS, a, L, and c are fixed (AS = 1, a = 100, L = 1/30, c < 1). With AM > 1 at low agonist concentrations, the second HOTSM response level is below the start level when b < 1, Fig 6A and B, and above when b > 1, Fig 6C and D.
b | b·d | AM > 1 | AM < 1 | Fig |
|---|---|---|---|---|
<1 | ≥1 | reverse bell-shaped, mono-phasic, terraced | terraced | 6A |
<1 | =0.5 | reverse bell-shaped, mono-phasic, terraced, mono-phasic | mono-phasic, bell-shaped | - |
<1 | <0.5 | reverse bell-shaped, mono-phasic, terraced, mono-phasic bell-shaped | bell-shaped | 6B & Fig 2 D |
>1 | ≥1 | terraced | terraced | 6C |
>1 | ≤0.5 | terraced, mono-phasic, bell-shaped | bell-shaped | 6D |