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Figure 8 | BMC Pharmacology

Figure 8

From: A homotropic two-state model and auto-antagonism

Figure 8

A principal drawing of the three plateaus for the functional-HOTSM. Parameters that determine each plateau are indicated to the right. The first plateau is determined by the fraction of R* conformations in the absence of ligands. When maximal fractions of SRS and SR*S are obtained at high ligand concentrations, the level of response is given by the four parameters a, b, d, and L, see Fig 1, and not dependent on either c, AS, or AM. The three latter parameters determine the width and the mid-point position at the concentration axis of the second plateau of response.

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