Figure 6

Dose-response relationships for the functional-HOTSM varying parameter A_M in five steps from 10^-4 (—) to 10⁴ (-..-..-..) by a factor 100. Other parameters were varied as indicated. In panels A and B, b < 1, and in panels C and D, b > 1. The third plateau, 1/[1+1/(L·a·b·d)], is above the first and second plateaus in panels A and C and below the first plateau in panels B and D. With conditions b < 1 and TP > FP, the HOTSM results in reverse bell-shaped dose-effect curves, panels A to C. For the conditions a and b > 1, the second plateau is always above the first plateau, panels B and D.