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Figure 5 | BMC Pharmacology

Figure 5

From: A homotropic two-state model and auto-antagonism

Figure 5

Dose-response relationships for the functional-HOTSM varying parameter AS in five steps from 10-4 (—) to 104 (-..-..-..) by a factor 100. Other parameters were varied as indicated. In panels A and B, b is less than unity, in panels C and D, b is above unity. The third plateau, 1/[1+1/(L·a·b·d)], is above the first and second plateaus in A and C and below the first plateau in B and D. Thus, with conditions a and b > 1, the second plateau is always above the first plateau, panels B and D.

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