Figure 3

Examples of varying parameter b for the functional-HOTSM dose-responses. Panel A, parameter b is varied in five steps increasing by a factor 10 from 10^-2 (—) to 100 (-..-..-..) with the other parameters fixed as indicated. Panel B is a 3 dimensional plot of separately changing the ligand concentration at either the orthosteric site, "O", the modulator site, "M", or simultaneously at both sites. Such 3-D plots are relevant for the switch from the HOTSM to the ATSM. Notice that a = 100 is above b = 10, and compare with figure 4B.