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Figure 10 | BMC Pharmacology

Figure 10

From: A homotropic two-state model and auto-antagonism

Figure 10

Examples of the concentration-binding relationships for HOTSM when varying parameters L or c in five steps from 10-4 (—) to 104 (-..-..-..) by a factor 100. Other parameters were varied as indicated. With a > 1 and increasing ligand concentrations, parameter L is the sole system constant that can move the concentration-binding curves for HOTSM either to the left, for b > 1, panel A, or to the right, for b < 1, panel B. Examples of varying parameters c, b and AS are shown in panels C and D. The effects of increasing parameter L, c and the other five parameter on the position and steepness of the concentration-binding curves for the HOTSM are summarized in table 3.

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