BMC Pharmacology

Table 1 Effect of the PDE inhibitors on the activity of PDE3 and PDE4. Data are presented as means ± S.E.M except in the case PDE3 where a satisfactory IC₅₀ for 3 of the compounds could not be calculated.

From: EMD273316 & EMD95833, type 4 phosphodiesterase inhibitors, stimulate fibroblastic-colony formation by bone marrow cells via direct inhibition of PDE4 and the induction of endogenous prostaglandin synthesis

PDE inhibitor	PDE3	PDE4
EMD95833	33% inhibition at 3 μM	IC₅₀ = 0.1 ± 0.004 μM
EMD219906	IC₅₀ = 1.3 ± 0.06 μM	IC₅₀ = 0.48 ± 0.03 μM
EMD249615	39% inhibition at 3 μM	IC₅₀ = 0.074 ± 0.004 μM
EMD273316	46% inhibition at 3 μM	IC₅₀ = 0.33 ± 0.01 μM

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