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Figure 4 | BMC Pharmacology

Figure 4

From: EMD273316 & EMD95833, type 4 phosphodiesterase inhibitors, stimulate fibroblastic-colony formation by bone marrow cells via direct inhibition of PDE4 and the induction of endogenous prostaglandin synthesis

Figure 4

Interaction between PDE4 inhibitors and PGE2. CFU-f cultures were carried out as described in Fig. 1 and the cells treated with 1 μM EMD273316, EMD95833, EMD249615 or EMD219906 in the presence or absence of 1 nM PGE2. Data presented are mean colony numbers per Petri dish ± S.D. * Denotes significant difference from control cultures, p < 0.05; # denotes significant difference from corresponding PGE2-free cultures, p < 0.05.

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