Figure 2

(A-C): ischemia + 1 day recovery: prominent ultrastructural damages of CA1 area of the hippocampus in the site of carotid artery occlusion. In particular, are displayed vacuolated neurons with irregular nuclei and margination of the heterochromatin (pre-apoptotic neurons). Large electron light vacuoles occupy the cytoplasm and the mitochondria are dense and disorganized. In many cells, vacuoles occupy the entire cytoplasm, cell shape is not maintained and the chromatin is dispersed into the cytoplasm (see A). (magnification × 3800). (D) M40401 (40 mg/kg) protected against damage. Indeed, the micrographs show the presence, in the hypothalamic CA1 area of normal neurons with large nuclei with euchromatin and prominent nucleoli. In addition, developed mitochondria, rough endoplasmic reticulum and normal cytoskeleton components are distinguished. In the extracellular space are found preserved myelinic fibers and blood vessels. (magnification × 3800)