Table 4 UM-1 and UM-2 production after incubation with S-F.
From: The stereospecificity of flobufen metabolism in isolated guinea pig hepatocytes
|  | peak area (AU × s × 104) | |||
|---|---|---|---|---|
| Â | incubation time (h) | |||
| Â | 2 | 4 | 8 | 24 |
|  | 25 μM | |||
UM-1 | - | - | - | 11.8 ± 0.6 |
UM-2 | 20.5 ± 1.3 | 48.8 ± 4.3 | 58.2 ± 3.8 | 135.6 ± 7.8 |
|  | 50 μM | |||
UM-1 | - | - | - | 23.8 ± 1.5 |
UM-2 | 30.5 ± 2.5 | 68.7 ± 4.4 | 119.7 ± 9.3 | 209.5 ± 10.3 |
|  | 75 μM | |||
UM-1 | - | - | - | 22.7 ± 3.6 |
UM-2 | 33.8 ± 1.6 | 78.1 ± 4.0 | 156.3 ± 6.3 | 270.3 ± 0.5 |
|  | 100 μM | |||
UM-1 | - | - | - | 20.3 ± 12.6 |
UM-2 | 35.1 ± 4.5 | 89.6 ± 0.7 | 188.1 ± 3.5 | 333.8 ± 7.8 |
|  | 200 μM | |||
UM-1 | - | - | - | 54.3 ± 0.5 |
UM-2 | 45.2 ± 6.6 | 116.2 ± 0.1 | 298.8 ± 0.5 | 549.6 ± 22.5 |