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Table 2 UM-1 and UM-2 production after incubation with rac-F.

From: The stereospecificity of flobufen metabolism in isolated guinea pig hepatocytes

 

peak area (AU × s × 104)

 

incubation time (h)

 

2

4

8

24

 

25 μM

UM-1

-

-

-

5.1 ± 0.1

UM-2

23.6 ± 1.1

46.8 ± 2.4

66.8 ± 1.2

120.0 ± 1.2

 

50 μM

UM-1

-

-

-

17.3 ± 1.1

UM-2

27.9 ± 0.4

67.3 ± 2.6

127.1 ± 6.7

185.2 ± 4.1

 

75 μM

UM-1

-

-

-

24.8 ± 4.0

UM-2

29.8 ± 1.7

79.3 ± 3.4

164.1 ± 10.2

250.0 ± 27.0

 

100 μM

UM-1

-

-

-

41.9 ± 10.3

UM-2

30.9 ± 3.6

91.8 ± 2.7

206.8 ± 13.2

331.5 ± 26.2

 

200 μM

UM-1

-

-

-

42.6 ± 2.3

UM-2

23.4 ± 2.0

102.9 ± 6.1

277.2 ± 12.1

521.3 ± 34.1

  1. UM-1 and UM-2 production in isolated guinea pigs hepatocytes after incubation with rac-F (mean value ± S.D., n = 4).