From: The stereospecificity of flobufen metabolism in isolated guinea pig hepatocytes
 | peak area (AU × s × 104) | |||
---|---|---|---|---|
 | incubation time (h) | |||
 | 2 | 4 | 8 | 24 |
 | 25 μM | |||
UM-1 | - | - | - | 5.1 ± 0.1 |
UM-2 | 23.6 ± 1.1 | 46.8 ± 2.4 | 66.8 ± 1.2 | 120.0 ± 1.2 |
 | 50 μM | |||
UM-1 | - | - | - | 17.3 ± 1.1 |
UM-2 | 27.9 ± 0.4 | 67.3 ± 2.6 | 127.1 ± 6.7 | 185.2 ± 4.1 |
 | 75 μM | |||
UM-1 | - | - | - | 24.8 ± 4.0 |
UM-2 | 29.8 ± 1.7 | 79.3 ± 3.4 | 164.1 ± 10.2 | 250.0 ± 27.0 |
 | 100 μM | |||
UM-1 | - | - | - | 41.9 ± 10.3 |
UM-2 | 30.9 ± 3.6 | 91.8 ± 2.7 | 206.8 ± 13.2 | 331.5 ± 26.2 |
 | 200 μM | |||
UM-1 | - | - | - | 42.6 ± 2.3 |
UM-2 | 23.4 ± 2.0 | 102.9 ± 6.1 | 277.2 ± 12.1 | 521.3 ± 34.1 |