Skip to main content

Table 1 Contractile responses to extracellular nucleotides in human cerebral and omental arteries.

From: Potent P2Y6 receptor mediated contractions in human cerebral arteries

  Cerebral arteries Omental arteries
  pEC50 (-log mol/L) Emax (%) pEC50 (-log mol/L) Emax (%)
αβ-MeATP 6.0 ± 0.1 80 ± 8 6.2 ± 0.1 81 ± 2
UDP 5.5 ± 0.2 128 ± 16 2.7 ± 0.2 81 ± 9
UDPβS 6.8 ± 0.2 117 ± 8 - 0 ± 0
UTP 5.3 ± 0.2 110 ± 10 3.3 ± 0.1 96 ± 8
UTPγS 5.3 ± 0.1 131 ± 10 4.3 ± 0.1 105 ± 7
ADP 2.9 ± 0.1 91 ± 23 2.6 ± 0.2 96 ± 7
ADPβS 0.0 ± 0.0 - - 8 ± 4
ATP 3.0 ± 0.2 97 ± 25 3.2 ± 0.1 88 ± 6
ATPγS 4.8 ± 0.2 125 ± 8 4.4 ± 0.1 106 ± 11
  1. All nucleotides, except αβ-MeATP, were added after desensitisation of P2X receptors with 10 μmol/L αβ-MeATP. Contractions are expressed as percentage of an initial contraction induced by 60 mmol/L K+. Data are shown as Emax ± S.E.M. and pEC50 ± S.E.M of 6 experiments (patients).