Table 1 Contractile responses to extracellular nucleotides in human cerebral and omental arteries.
From: Potent P2Y6 receptor mediated contractions in human cerebral arteries
Cerebral arteries | Omental arteries | |||
|---|---|---|---|---|
pEC50 (-log mol/L) | Emax (%) | pEC50 (-log mol/L) | Emax (%) | |
αβ-MeATP | 6.0 ± 0.1 | 80 ± 8 | 6.2 ± 0.1 | 81 ± 2 |
UDP | 5.5 ± 0.2 | 128 ± 16 | 2.7 ± 0.2 | 81 ± 9 |
UDPβS | 6.8 ± 0.2 | 117 ± 8 | - | 0 ± 0 |
UTP | 5.3 ± 0.2 | 110 ± 10 | 3.3 ± 0.1 | 96 ± 8 |
UTPγS | 5.3 ± 0.1 | 131 ± 10 | 4.3 ± 0.1 | 105 ± 7 |
ADP | 2.9 ± 0.1 | 91 ± 23 | 2.6 ± 0.2 | 96 ± 7 |
ADPβS | 0.0 ± 0.0 | - | - | 8 ± 4 |
ATP | 3.0 ± 0.2 | 97 ± 25 | 3.2 ± 0.1 | 88 ± 6 |
ATPγS | 4.8 ± 0.2 | 125 ± 8 | 4.4 ± 0.1 | 106 ± 11 |