BMC Pharmacology

Table 5 Effect of carbenoxolone on muscle relaxant activity by accelerod test

From: Anticonvulsant, sedative and muscle relaxant effects of carbenoxolone in mice

Treatment	Dose	First trial (sec)	Second trial (sec)
Normal saline	10 ml/kg	300	300
Diazepam	1 mg/kg	7.6 ± 10.95**	24.96 ± 11.74**
Carbenoxolone	100 mg/kg	18.87 ± 6.57**	221.21 ± 37.55
	200 mg/kg	9.78 ± 1.60**	71.44 ± 38.25**
	300 mg/kg	3.55 ± 1.19**	33.46 ± 26.64**

Carbenoxolone and diazepam (i.p.) were injected 60 and 30 minutes respectively, before the first trial. Values are the mean ± SEM for 10 mice. **P < 0.01, Compared to control, Dunnett's test

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