Table 2 Anticonvulsant effect of carbenoxolone against seizure induced by maximal electroshock in mice
From: Anticonvulsant, sedative and muscle relaxant effects of carbenoxolone in mice
Treatment | Dose | Duration of tonic seizure (sec) | Seizure protection (%) | Mortality protection (%) |
|---|---|---|---|---|
Normal saline | 10 ml/kg | 17.57 ± 1.72 | 0 | 14.28 |
Diazepam | 0.25 mg/kg | 11.8 ± 0.48** | 0 | 100 |
|  | 0.5 mg/kg | 8.63 ± 0.21*** | 0 | 100 |
|  | 3 mg/kg | 6.06 ± 1.27*** | 14.3 | 100 |
Carbenoxolone | 100 mg/kg | 12.11 ± 2.28 | 14.3 | 85.7 |
|  | 200 mg/kg | 12.10 ± 2.04 | 14.3 | 87.7 |
|  | 300 mg/kg | 11.85 ± 1.61 | 14.3 | 60 |
|  | 400 mg/kg | 9.16 ± 1.71* | 28.6 | 14.28 |