From: Anticonvulsant, sedative and muscle relaxant effects of carbenoxolone in mice
Treatment | Dose | Onset of seizure(sec) | Duration of clonic seizure (sec) | Seizure protection (%) | Mortality protection (%) |
---|---|---|---|---|---|
Normal saline | 10 ml/kg | 50.83 ± 8.14 | 25.83 ± 4.47 | 0 | 0 |
Diazepam | 0.1 mg/kg | 45.58 ± 2.61 | 9.68 ± 0.49*** | 0 | 0 |
 | 0.5 mg/kg | 121.73 ± 4.91 | 7.9 ± 0.52*** | 0 | 100 |
 | 1 mg/kg | 439.61 ± 60.80*** | 4.7 ± 1.67*** | 42.8 | 100 |
 | 1.5 mg/kg | 587.18 ± 12.86*** | 0.71 ± 0.71*** | 85.7 | 100 |
 | 3 mg/kg | 600*** | 0*** | 100 | 100 |
Carbenoxolone | 100 mg/kg | 213.14 ± 66.59 | 6.35 ± 1.55*** | 14.3 | 57.14 |
 | 200 mg/kg | 388.9 ± 71.74* | 3.28 ± 1.06*** | 28.6 | 57.14 |
 | 300 mg/kg | 464.9 ± 66.6** | 3 ± 1.91*** | 57.14 | 28.6 |