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Table 1 Anticonvulsant effect of carbenoxolone in the pentylenetetrazole-induced convulsion in mice

From: Anticonvulsant, sedative and muscle relaxant effects of carbenoxolone in mice

Treatment

Dose

Onset of seizure(sec)

Duration of clonic seizure (sec)

Seizure protection (%)

Mortality protection (%)

Normal saline

10 ml/kg

50.83 ± 8.14

25.83 ± 4.47

0

0

Diazepam

0.1 mg/kg

45.58 ± 2.61

9.68 ± 0.49***

0

0

 

0.5 mg/kg

121.73 ± 4.91

7.9 ± 0.52***

0

100

 

1 mg/kg

439.61 ± 60.80***

4.7 ± 1.67***

42.8

100

 

1.5 mg/kg

587.18 ± 12.86***

0.71 ± 0.71***

85.7

100

 

3 mg/kg

600***

0***

100

100

Carbenoxolone

100 mg/kg

213.14 ± 66.59

6.35 ± 1.55***

14.3

57.14

 

200 mg/kg

388.9 ± 71.74*

3.28 ± 1.06***

28.6

57.14

 

300 mg/kg

464.9 ± 66.6**

3 ± 1.91***

57.14

28.6

  1. Carbenoxolone and diazepam (i.p.) were injected 60 and 30 minutes respectively, before the administration of pentylenetetrazole (i.p. 90 mg/kg). Values are the mean ± SEM for 7 mice. *P < 0.05, **P < 0.01, ***P < 0.001, Compared to control, Tukey-Kramer Test.