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Table 6 Assumptions concerning the origin of the variation of transgene expression after adenoviral transfection.

From: Pharmacogenetic heterogeneity of transgene expression in muscle and tumours

Transfection

Variation

Different Tissues

Infection

 

w / wo

 

Transcription

Different Individuals

Transfection

  1. The difference of transgene expression between tissues of different histological origin is mainly due to differences in infectibility coupled in some cases with differences in transfection efficiency. The infectibility of a specific tissue is similar between individuals. However the transcription efficiency may vary greatly with subsequent large difference of transgene expression between two individuals.
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BMC Pharmacology

ISSN: 1471-2210