Table 1 Criteria for scoring muscle damage. The pathological changes were graded on 4 transversal sections of the right gastrocnemius. The total damage score is a compilation of scores of apoptosis, hyaline degeneration, myoblasts regeneration, and inflammation. All scores are ranging from 0 to 3.
From: Pharmacogenetic heterogeneity of transgene expression in muscle and tumours
| Â | Score | |||
|---|---|---|---|---|
| Â | 0 | 1 | 2 | 3 |
Apoptosis Number of apoptotic cells / bodies in 10 random 20 × magnification fields | 0–1 | <5 | 5–13 | >13 |
Hyaline degeneration Percentage of fibers affected. | 0–1% | 1–10 % | 10–50% | > 50% |
Myoblasts Number of myoblasts in 10 random 20 × magnification fields | 0–1 | <5 | 5–13 | >13 |
Inflammation Diffuse or multifocal inflammation in muscle fibers | Normal background | Increase of inflammatory cells | Aggregates of inflammatory cells | Aggregates of inflammatory cells obscuring the muscle architecture |