An MCASE approach to the search of a cure for Parkinson's Disease.

BMC Pharmacology

Table 3 Some biophores of MAO, NMDA and DA databases^a

#	biophores	PRA^b	A\I\M^c	#	Biophores	PRA	A\I\M
	MAO (selectivity approach)				MAO (activity approach)
1		100.0	44\0\0	4		99.90	30\0\0
2		99.37	12\0\1	5		100.0	51\0\5
3		99.98	12\0\0	6		99.99	13\0\1
NMDA
7		91.67	10\0\0	9		91.30	20\1\0
8		88.00	21\2\2	10		81.82	17\3\0
DA
11		100.0	82\2\5	14		93.75	18\0\0
12		99.98	54\3\6	15		100.0	22\1\0
13		93.75	14\1\0	16		93.75	9\1\0

^a Thickened lines represent biophores, dashed lines reflects general structural backbone around the biophore, in which side chains can occur. Sites of common branching are shown with shortened bonds. ^b PRA – MCASE calculated probability (%) that the biophore is relevant to activity. ^c A\I\M – Number of Active, Inactive and Marginal compounds that contain this biophore