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Table 2 Results of testing databases with generic drug-like moleculesa

From: An MCASE approach to the search of a cure for Parkinson's Disease.

Database

DA

NMDA

MAO-B (Selectivity approach)

MAO-B (Activity approach)

Test set size

1251

975

1251

1251

Predicted activeb

25

13

0

4

Proved activec

8

3

0

0

  1. a FDA Rodent Carcinogenicity database [35] was the source of chemicals for the test sets b All compounds predicted to be "active" and with sufficient confidence level of the prediction c Predicted "active" chemicals, which activity was reported in the literature