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Table 4 Effect of the intraperitoneal doses of Crocus sativus stigma aqueous extract, diclofenac and dexamethasone on xylene-induced ear swelling in mice.

From: Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice

Treatment Dose Ear swelling (mg) Inhibition (%)
Control 10 ml/kg 7.6 ± 0.6
Diclofenac 15 mg/kg 3.9 ± 0.4*** 53.6
Dexamethasone 15 mg/kg 32+0 3*** 63.1
Extract 0.32 g/kg 5.0 ± 0.4 20.9
Extract 0.56 g/kg 4.3 ± 0.4* 32.6
Extract 0.8 g/kg 3.5 ± 0.5** 44.1
  1. The increase in weight caused by the irritant (xylene) was measured by subtracting the weight of the untreated left ear section from that of the treated right ear sections. Values are the mean ± S.E.M. for 7 mice, *P<0.05, **P<0.01, ***P<0.001, compared to control (normal saline), Tukey-Kramer.