Table 2 2. Effects of intracerebroventricular (Lateral ventricle) admnistration of increasing doses of clozapine on urodynamic and EMG parameters in anesthetized rats. Values are Mean ± S.E.M.
From: Central effects of clozapine in regulating micturition in anesthetized rats
| Â | Urodynamic parameters | EUS EMG parameters | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dose (nmoles) | BC (ml) | MV (ml) | RV (%) | PT (mm Hg) | CT (sec) | PP (mm Hg) | ET (sec) | HFO (mm Hg) | Phase 1 (%) | Phase 2 (%) | Phase 3 (%) | Burst Amp. (%) |
Control | 0.25 (± 0.027) | 0.16 (± 0.018) | 33 (± 7.4) | 2.9 (± 0.29) | 19.4 (± 1.5) | 12.4 (± 0.46) | 3.0 (± 0.28) | 1.6 (± 0.11) | 100 | 100 | 100 | 100 |
0.5 | 0.26 (± 0.026) | 0.11 *,b (± 0.02) | 54 * (± 8.5) | 3.6 (± 0.30) | 21.6 (± 3.0) | 12.0 (± 0.90) | 2.0 (± 0.33) | 1.4 (± 0.19) | 117 (± 9.4) | 68 * (± 13.9) | 95 (± 4.7) | 101 (± 7.0) |
5.0 | 0.30 (± 0.022) | 0.11 * (± 0.019) | 62 ** (± 3.8) | 3.3 (± 0 44) | 22.2 (± 25) | 12.6 (± 0 73) | 1.8 * (± 0.35) | 1.3 (± 0.07) | 128 (+15 1) | 54 ** (± 8.4) | 101 (± 10.0) | 94 (± 5.5) |
50 | 0.51 ** (± 0.11) | 0.084 ** (± 0.014) | 80 ** (± 5.2) | 7.2 ** (± 1.46) | 18.7 (± 1.9) | 13.6 (± 0.34) | 1.3 ** (± 0.39) | 0.6 ** (± 0.20) | 62 * (± 14.9) | 26 ** (± 9.9) | 50 * (± 14.9) | 65 * (± 17.2) |