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Table 2 2. Effects of intracerebroventricular (Lateral ventricle) admnistration of increasing doses of clozapine on urodynamic and EMG parameters in anesthetized rats. Values are Mean ± S.E.M.

From: Central effects of clozapine in regulating micturition in anesthetized rats

  Urodynamic parameters EUS EMG parameters
Dose (nmoles) BC (ml) MV (ml) RV (%) PT (mm Hg) CT (sec) PP (mm Hg) ET (sec) HFO (mm Hg) Phase 1 (%) Phase 2 (%) Phase 3 (%) Burst Amp. (%)
Control 0.25 (± 0.027) 0.16 (± 0.018) 33 (± 7.4) 2.9 (± 0.29) 19.4 (± 1.5) 12.4 (± 0.46) 3.0 (± 0.28) 1.6 (± 0.11) 100 100 100 100
0.5 0.26 (± 0.026) 0.11 *,b (± 0.02) 54 * (± 8.5) 3.6 (± 0.30) 21.6 (± 3.0) 12.0 (± 0.90) 2.0 (± 0.33) 1.4 (± 0.19) 117 (± 9.4) 68 * (± 13.9) 95 (± 4.7) 101 (± 7.0)
5.0 0.30 (± 0.022) 0.11 * (± 0.019) 62 ** (± 3.8) 3.3 (± 0 44) 22.2 (± 25) 12.6 (± 0 73) 1.8 * (± 0.35) 1.3 (± 0.07) 128 (+15 1) 54 ** (± 8.4) 101 (± 10.0) 94 (± 5.5)
50 0.51 ** (± 0.11) 0.084 ** (± 0.014) 80 ** (± 5.2) 7.2 ** (± 1.46) 18.7 (± 1.9) 13.6 (± 0.34) 1.3 ** (± 0.39) 0.6 ** (± 0.20) 62 * (± 14.9) 26 ** (± 9.9) 50 * (± 14.9) 65 * (± 17.2)
  1. * p < 0.05 compared to control; ** p < 0.01 compared to control; a p < 0.05 compared to same dose, different route; b p < 0.01 compared to same dose, different route