Table 1 1. Effects of intrathecal (L6/S1 spinal level) administration increasing doses of clozapine on urodynamic and EMG parameters in anesthetized rats. Values are Mean ± S.E.M.

Control

0.29 (± 0.04)

0.18 (± 0.022)

34 (± 7.5)

3.4 (± 0.46)

16.9 (± 1.32)

13.1 (± 0.82)

2.4 (± 0.30)

1.5 (± 0.10)

100

100

100

100

0.5

0.30 (± 0.02)

0.17 (± 0.018)

43 (± 4.1)

3.3 (± 0.79)

17.0 (± 2.00)

13.3 (± 1.20)

1.9 (± 0.55)

1.3 (± 0.26)

98 (± 10.3)

89 (± 26.9)

116 (± 12.0)

84 (± 17.0)

5.0

0.32 (± 0.06)

0.11 ^** (± 0.031)

69 ^** (± 6.2)

3.3 (± 0.49)

22.1 (± 1.49)

12.3 (± 0.66)

0.7 ^**,a (± 0.46)

0.4 ^**,b (± .23)

91 (± 20.0)

37 ^* (± 24.0)

94.7 (± 21.8)

32 ^**,a (± 20.5)

50

0.47 ^** (± 0.09)

0.08 ^** (± 0.019)

79 ^** (± 4.3)

6.0 ^** (± 0.86)

21 (± 3.39)

13.6 (± 0.72)

0.9 ^* (± 0.93)

0.5 ^** (± 0.19)

93 (± 24)

40 ^* (± 14.0)

72 (± 14.8)

66 (± 22.2)