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Table 1 1. Effects of intrathecal (L6/S1 spinal level) administration increasing doses of clozapine on urodynamic and EMG parameters in anesthetized rats. Values are Mean ± S.E.M.

From: Central effects of clozapine in regulating micturition in anesthetized rats

  Urodynamic parameters EUS EMG parameters
Dose (nmoles) BC (ml) MV (ml) RV (%) PT (mm Hg) CT (sec) PP (mm Hg) ET (sec) HFO (mm Hg) Phase 1 (%) Phase 2 (%) Phase 3 (%) Burst Amp. (%)
Control 0.29 (± 0.04) 0.18 (± 0.022) 34 (± 7.5) 3.4 (± 0.46) 16.9 (± 1.32) 13.1 (± 0.82) 2.4 (± 0.30) 1.5 (± 0.10) 100 100 100 100
0.5 0.30 (± 0.02) 0.17 (± 0.018) 43 (± 4.1) 3.3 (± 0.79) 17.0 (± 2.00) 13.3 (± 1.20) 1.9 (± 0.55) 1.3 (± 0.26) 98 (± 10.3) 89 (± 26.9) 116 (± 12.0) 84 (± 17.0)
5.0 0.32 (± 0.06) 0.11 ** (± 0.031) 69 ** (± 6.2) 3.3 (± 0.49) 22.1 (± 1.49) 12.3 (± 0.66) 0.7 **,a (± 0.46) 0.4 **,b (± .23) 91 (± 20.0) 37 * (± 24.0) 94.7 (± 21.8) 32 **,a (± 20.5)
50 0.47 ** (± 0.09) 0.08 ** (± 0.019) 79 ** (± 4.3) 6.0 ** (± 0.86) 21 (± 3.39) 13.6 (± 0.72) 0.9 * (± 0.93) 0.5 ** (± 0.19) 93 (± 24) 40 * (± 14.0) 72 (± 14.8) 66 (± 22.2)
  1. * p < 0.05 compared to control; ** p < 0.01 compared to control; a p < 0.05 compared to same dose, different route; b p < 0.01 compared to same dose, different route