Figure 4

Effect of clozapine i.t. or i.c.v on pressure threshold and peak pressure. Data from intravenous administration [12] are shown for comparison. A) Pressure threshold increased only after the highest dose (50 nmoles) of clozapine either i.t. or i.c.v.; B) Clozapine i.t. or i.c.v. had no effect on the peak pressure. V= vehicle administration (saline) for i.t. or i.c.v. groups; (V) = vehicle administration for i.v. group. ^* = p < 0.05; ^** = p < 0.01