Figure 2

Representative traces of the effects of clozapine administered intracerebroventricularly (lateral ventricle) on the cystometrogram and activity of the external urethral sphincter of anesthetized rats. A & B) CMG after giving saline i.c.v. C & D) 0.5 nmoles of clozapine i.c.v. did not show appreciable effects on the CMG or the EUS EMG. E & F) CMG after 5 nmoles of clozapine i.c.v. Note a reduction in expulsion time and the amplitude of the HFO. G & H) 50 nmoles of clozapine i.c.v. increased the bladder capacity. However, the HFO are still present although reduced. In none of the rats were the HFO abolished by clozapine i.c.v contrasting the effects observed after spinal administration (Fig. 1). Non-voiding contractions are observed in this animal prior to the final voiding contraction (2G). Calibration bar: A, C,E,G = 1 min; B,D,F,H = 1 sec.